Through transcriptional activation, saRNA therapeutics promise a revolution in our ability to modulate previously undruggable targets.

Through transcriptional activation, saRNA therapeutics promise a revolution in our ability to modulate previously undruggable targets.

DEVELOPMENT PROGRAMS

MTL-CEBPA

The CEBPA gene encodes CCAAT/enhancer binding protein alpha (C/EBP-α), a transcription factor that acts as a master regulator of cell lineage determination and differentiation of myeloid cells and other cells types around the body. Myeloid cells are frequently dysregulated in the microenvironment of solid tumours and are understood to be an important resistance hurdle for many anti-cancer medicines. Restoring CEBPA expression in myeloid cells is hypothesised to alter immune cell populations in the tumour microenvironment and improve the efficacy of cancer therapies in solid tumour malignancies.

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